In Addition to the Inflammatory Infection, wWhat Other Factors Can Cause Interstitial Cystitis?

Date:2018-12-02 click:0

IC (Interstitial cystitis) is not relatively common in clinic; but the disease brings many discomforts like pelvic pain and urinary incontinence to the patients. Therefore, the "Diagnosis and treatment of urinary incontinence and pelvic floor reconstruction center" was set up in the first half of this year in a Shanghai University, which brings the dawn to the patients. 

In clinic, there are many causes of IC. Through the Biopsy and cystoscopy reports, it most shows the chronic inflammatory lesions of bladder. But when doing the routine urine analysis or culture, many patients aren't found to have pathogens. So, it can be found that inflammatory infection is not the main factor for interstitial cystitis. Then, in addition to the inflammatory infection, what other factors can cause IC?
Neurogenic stimulation 
Through clinical investigation of IC patients, it found that many patients have pelvic floor muscle dysfunction and sacral neuritis. Through the implementation of nerve treatment for these patients, their symptoms can be relieved effectively. For example, the neuronal stimulation and sensitivity can be reduced through the pelvic floor artificial physical therapy. In addition, the transcutaneous electrical nerve stimulation therapy is also widely used in the treatment of interstitial cystitis.
Autoimmune deficiencies
Many scholars believe that interstitial cystitis is an autoimmune collagen disease. Especially, some parts of the patients accompanied by systemic lupus erythematosus; another parts of patients with IC are effective on immunosuppressants. However, the occurrence rate of these complications is not commonly. So this factor is remaining to be proven.
Mast cell infiltration and the changes of epithelial permeability
Through the cystoscopy of interstitial cystitis, it can be found that the lower bladder mucosa and the detrusor muscle of many patients have a large number of functionally active mast cell infiltrations; In addition, the patients have enhanced mucosal permeability, causing the chemicals spill over into the submucosa. Therefore, when the chemicals stimulate the nerve source, the patients have the symptoms of pain and discomforts in the pelvic area.
All in all, no matter what the causes of interstitial cystitis are, for the recurrent hematuria, bladder or pelvic discomforts, after the exclusion of other diseases, the patients are likely to have interstitial cystitis. Once diagnosed by cystoscopy and biopsy, IC patients can take the conserved diuretic and anti-inflammatory pill to get a cure.